Transfer hydrogenations catalyzed by streptavidin-hosted secondary amine organocatalysts
نویسندگان
چکیده
Streptavidin-based secondary amine enables organocatalytic hydride reduction.
منابع مشابه
Molecular recognition of ketomalonates by asymmetric aldol reaction of aldehydes with secondary-amine organocatalysts.
A diastereo- and enantioselective aldol reaction between aldehydes and a synthetically useful ketomalonate 1c as a hydrated form was developed, and either anti- or syn-aldol adducts having a chiral tetrasubstituted carbon center were obtained in high enantioselectivities by use of a tetrazole analogue of L-proline (S)-2 or an axially chiral amino sulfonamide (S)-3 as catalyst.
متن کاملDesign of Modified Amine Transfer Reagents Allows the Synthesis of α-Chiral Secondary Amines via CuH-Catalyzed Hydroamination
The CuH-catalyzed hydroamination of alkenes and alkynes using a silane and an amine transfer reagent represents a simple strategy to access chiral amine products. We have recently reported methods to prepare chiral amines with high efficiency and stereoselectivity using this approach. However, the current technology is limited to the synthesis of trialkylamines from dialkylamine transfer reagen...
متن کاملAn Efficient Synthesis of Benzylamino Coumarin Derivatives via Three-component Coupling of 4-hydroxycoumarin, Aromatic Aldehyde and Cyclic Secondary Amine Catalyzed by CuO Nanoparticles
A green and efficient one-pot synthesis of benzylamino coumarin derivatives was conducted by a three-component condensation of 4-hydroxycoumarin, cyclic secondary amine, and aromatic aldehyde in the presence of CuO nanoparticles (NPs) as a heterogeneous catalyst in water at room temperature.
متن کاملA Simple Setup for Transfer Hydrogenations in Flow Chemistry
By using a packed-bed reactor with a palladium/charcoal catalyst and ammonium formate or triethylsilane as hydrogen/hydride source, various functional groups including nitro groups, azides and alkenes can be efficiently reduced by a transfer hydrogenation process under mild conditions in a simple flow system.
متن کاملAsymmetric Transfer Hydrogenations of 2,3-Disubstituted Quinoxalines with Ammonia Borane.
An asymmetric transfer hydrogenation of 2,3-disubstituted quinoxalines using a chiral frustrated Lewis pair of Piers' borane and (R)-tert-butylsulfinamide as the catalyst with ammonia borane as the hydrogen source has been successfully realized. For 2-alkyl-3-arylquinoxaline substrates, cis-tetrahydroquinoxalines were obtained as the predominant products in high yields with 77-86% ee. In contra...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical Communications
سال: 2021
ISSN: ['1359-7345', '1364-548X']
DOI: https://doi.org/10.1039/d0cc08142f